Drug interactions
Chlorpromazine + Olodaterol inhaled
Severity: Moderate
Chlorpromazine and Olodaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine prolongs the QT interval, and beta2 agonists such as olodaterol may produce tachycardia, hypokalemia and QT changes. Together they may increase the risk of ventricular arrhythmias, though systemic exposure from inhaled olodaterol is low.
What this interaction means in plain words
Chlorpromazine and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and beta2-mediated hypokalemia and tachycardia.
What to do
Check baseline ECG and potassium in patients with additional QT risk factors, and correct electrolyte abnormalities. Monitor for palpitations or syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Olodaterol inhaled?
MediHelp rates the interaction as moderate. Chlorpromazine and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine prolongs the QT interval, and beta2 agonists such as olodaterol may produce tachycardia, hypokalemia and QT changes. Together they may increase the risk of ventricular arrhythmias, though systemic exposure from inhaled olodaterol is low.
How serious is the interaction between Chlorpromazine and Olodaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and potassium in patients with additional QT risk factors, and correct electrolyte abnormalities. Monitor for palpitations or syncope.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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