Drug interactions
Chlorpromazine + Olopatadine intranasal
Severity: Moderate
Chlorpromazine and Olopatadine intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine is sedating and intranasal olopatadine can cause drowsiness, so together they may increase CNS depression and impair psychomotor performance.
What this interaction means in plain words
Chlorpromazine and Olopatadine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic sedation from antihistamine and phenothiazine effects.
What to do
Warn the patient about drowsiness and avoid driving or hazardous tasks. Consider a non-sedating nasal alternative if sedation is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Olopatadine intranasal?
MediHelp rates the interaction as moderate. Chlorpromazine and Olopatadine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine is sedating and intranasal olopatadine can cause drowsiness, so together they may increase CNS depression and impair psychomotor performance.
How serious is the interaction between Chlorpromazine and Olopatadine intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn the patient about drowsiness and avoid driving or hazardous tasks. Consider a non-sedating nasal alternative if sedation is troublesome.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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