Drug interactions
Chlorpromazine + Phendimetrazine
Severity: Moderate
Chlorpromazine and Phendimetrazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phendimetrazine is a sympathomimetic stimulant that can raise heart rate and blood pressure, while chlorpromazine has sedative, hypotensive and QT-prolonging effects. Their actions partly oppose each other, and antipsychotics may reduce the anorectic effect of stimulants.
What this interaction means in plain words
Chlorpromazine and Phendimetrazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic opposition (dopamine blockade versus sympathomimetic stimulation) with possible additive cardiac effects.
What to do
Monitor blood pressure, heart rate and ECG in patients with cardiac risk factors. Reassess the need for the anorectic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Phendimetrazine?
MediHelp rates the interaction as moderate. Chlorpromazine and Phendimetrazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phendimetrazine is a sympathomimetic stimulant that can raise heart rate and blood pressure, while chlorpromazine has sedative, hypotensive and QT-prolonging effects. Their actions partly oppose each other, and antipsychotics may reduce the anorectic effect of stimulants.
How serious is the interaction between Chlorpromazine and Phendimetrazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and ECG in patients with cardiac risk factors. Reassess the need for the anorectic.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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