Drug interactions
Chlorpromazine + Quazepam
Severity: Moderate
Chlorpromazine and Quazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a phenothiazine antipsychotic with a benzodiazepine hypnotic increases sedation, dizziness and psychomotor impairment. Respiratory depression and falls are more likely in elderly or debilitated patients.
What this interaction means in plain words
Chlorpromazine and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through dopaminergic, histaminergic and GABA-A mediated effects.
What to do
Use the lowest effective doses and monitor sedation and respiratory status. Advise patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Quazepam?
MediHelp rates the interaction as moderate. Chlorpromazine and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a phenothiazine antipsychotic with a benzodiazepine hypnotic increases sedation, dizziness and psychomotor impairment. Respiratory depression and falls are more likely in elderly or debilitated patients.
How serious is the interaction between Chlorpromazine and Quazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and respiratory status. Advise patients to avoid driving and alcohol.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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