Drug interactions
Chlorpromazine + Quinacrine
Severity: Minor
Chlorpromazine and Quinacrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinacrine may inhibit CYP2D6, which contributes to chlorpromazine metabolism. Higher chlorpromazine concentrations could increase sedation, hypotension, extrapyramidal symptoms and QT effects.
What this interaction means in plain words
Chlorpromazine and Quinacrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of CYP2D6-mediated chlorpromazine metabolism.
What to do
Monitor for increased sedation, hypotension and extrapyramidal effects. Adjust the chlorpromazine dose if adverse effects appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Quinacrine?
MediHelp rates the interaction as minor. Chlorpromazine and Quinacrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinacrine may inhibit CYP2D6, which contributes to chlorpromazine metabolism. Higher chlorpromazine concentrations could increase sedation, hypotension, extrapyramidal symptoms and QT effects.
How serious is the interaction between Chlorpromazine and Quinacrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation, hypotension and extrapyramidal effects. Adjust the chlorpromazine dose if adverse effects appear.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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