Drug interactions
Chlorpromazine + Quinapril
Severity: Minor
Chlorpromazine and Quinapril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine has alpha-blocking and vasodilating properties that can add to the blood-pressure-lowering effect of ACE inhibitors such as quinapril. Patients may experience orthostatic hypotension, especially at initiation or after dose increases.
What this interaction means in plain words
Chlorpromazine and Quinapril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive hypotensive effect from alpha-1 adrenergic blockade (chlorpromazine) and ACE inhibition (quinapril).
What to do
Monitor blood pressure and orthostatic symptoms when starting or changing either drug. Advise patients to rise slowly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Quinapril?
MediHelp rates the interaction as minor. Chlorpromazine and Quinapril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chlorpromazine has alpha-blocking and vasodilating properties that can add to the blood-pressure-lowering effect of ACE inhibitors such as quinapril. Patients may experience orthostatic hypotension, especially at initiation or after dose increases.
How serious is the interaction between Chlorpromazine and Quinapril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or changing either drug. Advise patients to rise slowly.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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