Drug interactions
Chlorpromazine + Sodium picosulfate / magnesium oxide / anhydrous citric acid
Severity: Moderate
Chlorpromazine and Sodium picosulfate / magnesium oxide / anhydrous citric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The magnesium-containing bowel preparation may bind chlorpromazine in the gut and reduce its absorption. Bowel cleansing also speeds transit and fluid shifts that can alter drug exposure.
What this interaction means in plain words
Chlorpromazine and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chelation or binding by magnesium cations and reduced absorption from faster transit.
What to do
Give oral chlorpromazine at least 2 hours before and about 6 hours after the preparation, and monitor clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates the interaction as moderate. Chlorpromazine and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The magnesium-containing bowel preparation may bind chlorpromazine in the gut and reduce its absorption. Bowel cleansing also speeds transit and fluid shifts that can alter drug exposure.
How serious is the interaction between Chlorpromazine and Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give oral chlorpromazine at least 2 hours before and about 6 hours after the preparation, and monitor clinical response.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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