Drug interactions
Chlorpromazine + Sodium sulfate / ?magnesium sulfate / potassium chloride
Severity: Moderate
Chlorpromazine and Sodium sulfate / ?magnesium sulfate / potassium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium in the bowel preparation can bind oral chlorpromazine and reduce its absorption. Bowel preparation related electrolyte disturbances may also add to the QT risk with chlorpromazine.
What this interaction means in plain words
Chlorpromazine and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chelation by magnesium reduces absorption, and electrolyte shifts potentiate QT prolongation.
What to do
Give chlorpromazine at least 2 hours before and about 6 hours after each dose of the preparation. Consider ECG and electrolyte checks in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates the interaction as moderate. Chlorpromazine and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Magnesium in the bowel preparation can bind oral chlorpromazine and reduce its absorption. Bowel preparation related electrolyte disturbances may also add to the QT risk with chlorpromazine.
How serious is the interaction between Chlorpromazine and Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give chlorpromazine at least 2 hours before and about 6 hours after each dose of the preparation. Consider ECG and electrolyte checks in patients with cardiac risk factors.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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