Drug interactions
Chlorpromazine + Triprolidine
Severity: Moderate
Chlorpromazine and Triprolidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine is a sedating phenothiazine with strong antihistaminic and anticholinergic activity. Combining it with triprolidine increases drowsiness, anticholinergic effects and risk of hypotension or confusion.
What this interaction means in plain words
Chlorpromazine and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Triprolidine belongs to Respiratory.
Why it happens
Additive CNS depression and additive antimuscarinic and antihistaminic effects.
What to do
Monitor for oversedation, urinary retention, constipation and confusion, particularly in older patients. Consider a non-sedating antihistamine instead.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triprolidine
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Triprolidine?
MediHelp rates the interaction as moderate. Chlorpromazine and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine is a sedating phenothiazine with strong antihistaminic and anticholinergic activity. Combining it with triprolidine increases drowsiness, anticholinergic effects and risk of hypotension or confusion.
How serious is the interaction between Chlorpromazine and Triprolidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation, urinary retention, constipation and confusion, particularly in older patients. Consider a non-sedating antihistamine instead.
What other medicines interact with Triprolidine?
MediHelp also lists interactions of Triprolidine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Triprolidine page.
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