Drug interactions
Chlorpromazine + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Chlorpromazine and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol, a long-acting beta-agonist, can affect cardiac repolarization, and chlorpromazine prolongs the QT interval. Together they may increase the risk of arrhythmia, although inhaled systemic exposure is low.
What this interaction means in plain words
Chlorpromazine and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, with beta-agonist-induced hypokalemia and tachycardia potentially increasing arrhythmia susceptibility.
What to do
Use at the labeled inhaled dose and monitor for palpitations, with ECG and potassium checks in patients with cardiac risk factors. Consider an alternative if QTc is already prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Chlorpromazine and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol, a long-acting beta-agonist, can affect cardiac repolarization, and chlorpromazine prolongs the QT interval. Together they may increase the risk of arrhythmia, although inhaled systemic exposure is low.
How serious is the interaction between Chlorpromazine and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use at the labeled inhaled dose and monitor for palpitations, with ECG and potassium checks in patients with cardiac risk factors. Consider an alternative if QTc is already prolonged.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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