Drug interactions
Chlorpromazine + Valoctocogene roxaparvovec
Severity: Moderate
Chlorpromazine and Valoctocogene roxaparvovec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valoctocogene roxaparvovec commonly causes transaminase elevations after infusion, and chlorpromazine has hepatotoxic potential, mainly cholestatic injury. Using both could make liver injury more likely or harder to interpret and could reduce the durability of factor VIII expression.
What this interaction means in plain words
Chlorpromazine and Valoctocogene roxaparvovec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Valoctocogene roxaparvovec belongs to Miscellaneous.
Why it happens
Additive hepatotoxic potential; this is a predicted pharmacodynamic effect rather than a well-established interaction.
What to do
Check liver enzymes regularly according to the gene therapy monitoring schedule and consider an alternative to chlorpromazine if transaminases rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlorpromazine and Valoctocogene roxaparvovec, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Valoctocogene roxaparvovec
Frequently asked questions
Can I take Chlorpromazine with Valoctocogene roxaparvovec?
MediHelp rates the interaction as moderate. Chlorpromazine and Valoctocogene roxaparvovec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valoctocogene roxaparvovec commonly causes transaminase elevations after infusion, and chlorpromazine has hepatotoxic potential, mainly cholestatic injury. Using both could make liver injury more likely or harder to interpret and could reduce the durability of factor VIII expression.
How serious is the interaction between Chlorpromazine and Valoctocogene roxaparvovec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check liver enzymes regularly according to the gene therapy monitoring schedule and consider an alternative to chlorpromazine if transaminases rise.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
