Drug interactions
Chlorpromazine + Vilanterol / fluticasone furoate inhaled
Severity: Moderate
Chlorpromazine and Vilanterol / fluticasone furoate inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol is a long-acting beta-agonist that may prolong QTc or provoke tachyarrhythmia, and chlorpromazine can prolong QT. The concern is mainly additive cardiac effects, with limited systemic exposure from inhalation.
What this interaction means in plain words
Chlorpromazine and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and beta-adrenergic cardiac stimulation, with possible beta-agonist-related hypokalemia.
What to do
Use the inhaler at the recommended dose and monitor for palpitations, with ECG and potassium checks in patients at cardiac risk. Choose an alternative if QTc is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as moderate. Chlorpromazine and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol is a long-acting beta-agonist that may prolong QTc or provoke tachyarrhythmia, and chlorpromazine can prolong QT. The concern is mainly additive cardiac effects, with limited systemic exposure from inhalation.
How serious is the interaction between Chlorpromazine and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the inhaler at the recommended dose and monitor for palpitations, with ECG and potassium checks in patients at cardiac risk. Choose an alternative if QTc is prolonged.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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