Drug interactions
Chlorpromazine + Yohimbe
Severity: Moderate
Chlorpromazine and Yohimbe: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbe contains yohimbine, an alpha-2 antagonist that raises sympathetic outflow and can cause anxiety, agitation, tachycardia and hypertension. This may counteract the sedative and antipsychotic effects of chlorpromazine and oppose its alpha-blocking hypotension. The evidence is limited.
What this interaction means in plain words
Chlorpromazine and Yohimbe can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Yohimbine's alpha-2 adrenergic antagonism and central noradrenergic stimulation oppose chlorpromazine's effects, with theoretical antagonism only.
What to do
Advise patients to avoid yohimbe products while taking chlorpromazine. Monitor blood pressure, heart rate and psychiatric symptoms if the patient has used it.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Yohimbe?
MediHelp rates the interaction as moderate. Chlorpromazine and Yohimbe can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbe contains yohimbine, an alpha-2 antagonist that raises sympathetic outflow and can cause anxiety, agitation, tachycardia and hypertension. This may counteract the sedative and antipsychotic effects of chlorpromazine and oppose its alpha-blocking hypotension. The evidence is limited.
How serious is the interaction between Chlorpromazine and Yohimbe?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid yohimbe products while taking chlorpromazine. Monitor blood pressure, heart rate and psychiatric symptoms if the patient has used it.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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