Drug interactions
Chlorpropamide + Erythromycin lactobionate
Severity: Minor
Chlorpropamide and Erythromycin lactobionate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macrolides have been reported to increase sulfonylurea effects, and both drugs can rarely cause cholestatic liver injury. The interaction is poorly characterized.
What this interaction means in plain words
Chlorpropamide and Erythromycin lactobionate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorpropamide belongs to Endocrine; Erythromycin lactobionate belongs to Anti Bacterial.
Why it happens
Mechanism not established; possible additive hepatotoxicity and altered sulfonylurea disposition.
What to do
Monitor blood glucose and liver function tests during combined use. Counsel on hypoglycemia and jaundice symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlorpropamide and Erythromycin lactobionate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Chlorpropamide
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Chlorpropamide with Erythromycin lactobionate?
MediHelp rates the interaction as minor. Chlorpropamide and Erythromycin lactobionate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Macrolides have been reported to increase sulfonylurea effects, and both drugs can rarely cause cholestatic liver injury. The interaction is poorly characterized.
How serious is the interaction between Chlorpropamide and Erythromycin lactobionate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and liver function tests during combined use. Counsel on hypoglycemia and jaundice symptoms.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
