Drug interactions
Chlorpropamide + Fluconazole
Severity: Moderate
Chlorpropamide and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole can raise chlorpropamide levels and prolong its glucose-lowering effect. This increases the risk of hypoglycemia, which may be prolonged in older patients or those with renal impairment.
What this interaction means in plain words
Chlorpropamide and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Fluconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP2C9 metabolism of chlorpropamide.
What to do
Monitor blood glucose closely and reduce the chlorpropamide dose if needed during fluconazole therapy. Educate patients on hypoglycemia symptoms or consider switching to another agent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Fluconazole?
MediHelp rates the interaction as moderate. Chlorpropamide and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole can raise chlorpropamide levels and prolong its glucose-lowering effect. This increases the risk of hypoglycemia, which may be prolonged in older patients or those with renal impairment.
How serious is the interaction between Chlorpropamide and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and reduce the chlorpropamide dose if needed during fluconazole therapy. Educate patients on hypoglycemia symptoms or consider switching to another agent.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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