Drug interactions
Chlorpropamide + Hydrochlorothiazide-irbesartan
Severity: Moderate
Chlorpropamide and Hydrochlorothiazide-irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides can raise blood glucose and reduce the effect of sulfonylureas such as chlorpropamide. Thiazides may also contribute to hyponatremia, which chlorpropamide can also cause.
What this interaction means in plain words
Chlorpropamide and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Hydrochlorothiazide-irbesartan belongs to Cardiovascular.
Why it happens
Thiazides impair insulin secretion and sensitivity; both agents can promote hyponatremia via effects on water handling.
What to do
Monitor blood glucose and serum sodium. Consider a safer sulfonylurea or adjust the diabetes regimen if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as moderate. Chlorpropamide and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides can raise blood glucose and reduce the effect of sulfonylureas such as chlorpropamide. Thiazides may also contribute to hyponatremia, which chlorpropamide can also cause.
How serious is the interaction between Chlorpropamide and Hydrochlorothiazide-irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum sodium. Consider a safer sulfonylurea or adjust the diabetes regimen if control worsens.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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