Drug interactions
Chlorpropamide + Hydrochlorothiazide
Severity: Moderate
Chlorpropamide and Hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can raise blood glucose and weaken the effect of chlorpropamide. Both drugs can also cause hyponatremia, so sodium may fall further when they are combined.
What this interaction means in plain words
Chlorpropamide and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Thiazides impair insulin secretion and glucose tolerance, and both drugs promote hyponatremia through effects on water and sodium handling.
What to do
Monitor blood glucose and serum sodium, and adjust the antidiabetic regimen as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Hydrochlorothiazide?
MediHelp rates the interaction as moderate. Chlorpropamide and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide can raise blood glucose and weaken the effect of chlorpropamide. Both drugs can also cause hyponatremia, so sodium may fall further when they are combined.
How serious is the interaction between Chlorpropamide and Hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum sodium, and adjust the antidiabetic regimen as needed.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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