Drug interactions
Chlorpropamide + Levoketoconazole
Severity: Moderate
Chlorpropamide and Levoketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azole antifungals inhibiting CYP2C9 can raise sulfonylurea concentrations and cause hypoglycemia. Levoketoconazole may also lower blood glucose in its own right in treated Cushing's patients, adding to the risk.
What this interaction means in plain words
Chlorpropamide and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Levoketoconazole belongs to Endocrine.
Why it happens
Inhibition of CYP2C9-mediated chlorpropamide metabolism.
What to do
Monitor blood glucose when starting levoketoconazole and lower the chlorpropamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpropamide
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Chlorpropamide with Levoketoconazole?
MediHelp rates the interaction as moderate. Chlorpropamide and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azole antifungals inhibiting CYP2C9 can raise sulfonylurea concentrations and cause hypoglycemia. Levoketoconazole may also lower blood glucose in its own right in treated Cushing's patients, adding to the risk.
How serious is the interaction between Chlorpropamide and Levoketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting levoketoconazole and lower the chlorpropamide dose if hypoglycemia occurs.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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