Drug interactions
Chlorpropamide + Methylprednisolone
Severity: Moderate
Chlorpropamide and Methylprednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic methylprednisolone raises blood glucose and can offset the effect of chlorpropamide, leading to loss of glycemic control, particularly with high doses or prolonged use.
What this interaction means in plain words
Chlorpropamide and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Methylprednisolone belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: glucocorticoids increase hepatic glucose output and insulin resistance.
What to do
Monitor blood glucose frequently during steroid therapy and adjust the sulfonylurea dose or add insulin if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Methylprednisolone?
MediHelp rates the interaction as moderate. Chlorpropamide and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic methylprednisolone raises blood glucose and can offset the effect of chlorpropamide, leading to loss of glycemic control, particularly with high doses or prolonged use.
How serious is the interaction between Chlorpropamide and Methylprednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently during steroid therapy and adjust the sulfonylurea dose or add insulin if needed.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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