Drug interactions
Chlorpropamide + Metolazone
Severity: Moderate
Chlorpropamide and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone can raise blood glucose and may reduce the effect of chlorpropamide. Both drugs can also cause hyponatraemia, so together the risk of low sodium may be increased.
What this interaction means in plain words
Chlorpropamide and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Metolazone belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism through impaired insulin secretion and sensitivity, plus additive effects on sodium and water handling.
What to do
Monitor blood glucose and serum sodium after starting metolazone and adjust antidiabetic therapy as needed. Consider an alternative sulfonylurea if hyponatraemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metolazone
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Metolazone?
MediHelp rates the interaction as moderate. Chlorpropamide and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metolazone can raise blood glucose and may reduce the effect of chlorpropamide. Both drugs can also cause hyponatraemia, so together the risk of low sodium may be increased.
How serious is the interaction between Chlorpropamide and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum sodium after starting metolazone and adjust antidiabetic therapy as needed. Consider an alternative sulfonylurea if hyponatraemia develops.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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