Drug interactions
Gliclazide + Pegvisomant
Severity: Moderate
Gliclazide and Pegvisomant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pegvisomant blocks growth hormone action, which increases insulin sensitivity and can lower glucose in diabetic patients. When used with gliclazide, the risk of hypoglycemia rises, and glucose-lowering drug doses often need to be reduced.
What this interaction means in plain words
Gliclazide and Pegvisomant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Pegvisomant belongs to Endocrine.
Why it happens
Growth hormone receptor antagonism reduces insulin resistance, adding to the insulin secretagogue effect of gliclazide.
What to do
Monitor blood glucose regularly after starting pegvisomant and reduce the gliclazide dose if glucose is falling or hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Pegvisomant
- Alogliptin-metformin + Pegvisomant Moderate
- Alogliptin-pioglitazone + Pegvisomant Moderate
- Chlorpropamide + Pegvisomant Moderate
- Codeine + Pegvisomant Moderate
- Dapagliflozin-metformin + Pegvisomant Moderate
- Ertugliflozin-sitagliptin + Pegvisomant Moderate
Frequently asked questions
Can I take Gliclazide with Pegvisomant?
MediHelp rates the interaction as moderate. Gliclazide and Pegvisomant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pegvisomant blocks growth hormone action, which increases insulin sensitivity and can lower glucose in diabetic patients. When used with gliclazide, the risk of hypoglycemia rises, and glucose-lowering drug doses often need to be reduced.
How serious is the interaction between Gliclazide and Pegvisomant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose regularly after starting pegvisomant and reduce the gliclazide dose if glucose is falling or hypoglycemia occurs.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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