Drug interactions
Chlorpropamide + Risperidone
Severity: Moderate
Chlorpropamide and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone can cause hyperglycemia and impair glucose tolerance, which may reduce the effectiveness of chlorpropamide. Glycemic control may worsen in diabetic patients.
What this interaction means in plain words
Chlorpropamide and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Risperidone belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism through risperidone-related insulin resistance and metabolic effects.
What to do
Monitor blood glucose and HbA1c when risperidone is started or the dose changed. Adjust the antidiabetic regimen if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Risperidone?
MediHelp rates the interaction as moderate. Chlorpropamide and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone can cause hyperglycemia and impair glucose tolerance, which may reduce the effectiveness of chlorpropamide. Glycemic control may worsen in diabetic patients.
How serious is the interaction between Chlorpropamide and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c when risperidone is started or the dose changed. Adjust the antidiabetic regimen if control worsens.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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