Drug interactions
Chlorpropamide + Rucaparib
Severity: Minor
Chlorpropamide and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP2C9 and may raise exposure to CYP2C9 substrates, which could enhance chlorpropamide's glucose-lowering effect. Chlorpropamide is only partly CYP2C9-dependent, so the effect is probably modest.
What this interaction means in plain words
Chlorpropamide and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorpropamide belongs to Endocrine; Rucaparib belongs to Oncology.
Why it happens
Rucaparib inhibits CYP2C9, reducing chlorpropamide metabolism.
What to do
Monitor blood glucose when rucaparib is started. Reduce the chlorpropamide dose if hypoglycemia develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlorpropamide
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Chlorpropamide with Rucaparib?
MediHelp rates the interaction as minor. Chlorpropamide and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib inhibits CYP2C9 and may raise exposure to CYP2C9 substrates, which could enhance chlorpropamide's glucose-lowering effect. Chlorpropamide is only partly CYP2C9-dependent, so the effect is probably modest.
How serious is the interaction between Chlorpropamide and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when rucaparib is started. Reduce the chlorpropamide dose if hypoglycemia develops.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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