Drug interactions
Chlorpropamide + Trimipramine
Severity: Minor
Chlorpropamide and Trimipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants may influence glucose levels, and combining them with a sulfonylurea such as chlorpropamide could occasionally increase the risk of hypoglycemia. Evidence is limited and the effect is generally small.
What this interaction means in plain words
Chlorpropamide and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorpropamide belongs to Endocrine; Trimipramine belongs to Central Nervous System.
Why it happens
Possible additive pharmacodynamic effect on glucose lowering; not well established.
What to do
Counsel the patient on hypoglycemia symptoms and monitor blood glucose when trimipramine is started, stopped or changed in dose; reduce the chlorpropamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Trimipramine?
MediHelp rates the interaction as minor. Chlorpropamide and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants may influence glucose levels, and combining them with a sulfonylurea such as chlorpropamide could occasionally increase the risk of hypoglycemia. Evidence is limited and the effect is generally small.
How serious is the interaction between Chlorpropamide and Trimipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient on hypoglycemia symptoms and monitor blood glucose when trimipramine is started, stopped or changed in dose; reduce the chlorpropamide dose if hypoglycemia occurs.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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