Drug interactions
Chlorthalidone + Hydrochlorothiazide-irbesartan
Severity: Moderate
Chlorthalidone and Hydrochlorothiazide-irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone is a second thiazide-type diuretic, so combining it with a hydrochlorothiazide-containing product duplicates therapy. This increases the risk of hypokalemia, hyponatremia, hypomagnesemia, volume depletion and hyperuricemia.
What this interaction means in plain words
Chlorthalidone and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Hydrochlorothiazide-irbesartan belongs to Cardiovascular.
Why it happens
Additive inhibition of the distal tubule sodium-chloride cotransporter causes excess electrolyte and fluid loss.
What to do
Avoid therapeutic duplication unless deliberately used for sequential nephron blockade. If combined, monitor electrolytes, renal function and blood pressure closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Chlorthalidone
Frequently asked questions
Can I take Chlorthalidone with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as moderate. Chlorthalidone and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone is a second thiazide-type diuretic, so combining it with a hydrochlorothiazide-containing product duplicates therapy. This increases the risk of hypokalemia, hyponatremia, hypomagnesemia, volume depletion and hyperuricemia.
How serious is the interaction between Chlorthalidone and Hydrochlorothiazide-irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid therapeutic duplication unless deliberately used for sequential nephron blockade. If combined, monitor electrolytes, renal function and blood pressure closely.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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