Drug interactions
Chlorthalidone + Vitamin d
Severity: Moderate
Chlorthalidone and Vitamin d: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone reduces urinary calcium excretion, and with vitamin D supplementation this can lead to hypercalcemia, especially at higher vitamin D doses or in people with hyperparathyroidism or renal impairment. Symptoms include nausea, constipation, polyuria and confusion.
What this interaction means in plain words
Chlorthalidone and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Vitamin d belongs to Gastrointestinal Tract.
Why it happens
Thiazide-type diuretics increase distal tubular calcium reabsorption, adding to vitamin D-enhanced intestinal calcium absorption.
What to do
Monitor serum calcium and renal function periodically, particularly after dose increases or when calcium supplements are also taken. Reduce vitamin D or calcium dose if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorthalidone
Other interactions of Vitamin d
Frequently asked questions
Can I take Chlorthalidone with Vitamin d?
MediHelp rates the interaction as moderate. Chlorthalidone and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone reduces urinary calcium excretion, and with vitamin D supplementation this can lead to hypercalcemia, especially at higher vitamin D doses or in people with hyperparathyroidism or renal impairment. Symptoms include nausea, constipation, polyuria and confusion.
How serious is the interaction between Chlorthalidone and Vitamin d?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and renal function periodically, particularly after dose increases or when calcium supplements are also taken. Reduce vitamin D or calcium dose if hypercalcemia develops.
What other medicines interact with Chlorthalidone?
MediHelp also lists interactions of Chlorthalidone with, for example, Amifostine, Atenolol-chlorthalidone, Candesartan-hydrochlorothiazide. The full list is on the Chlorthalidone page.
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