Drug interactions
Chlorzoxazone + Cinnarizine
Severity: Moderate
Chlorzoxazone and Cinnarizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinnarizine has sedating antihistamine properties and may add to chlorzoxazone-related drowsiness. This can impair concentration and coordination.
What this interaction means in plain words
Chlorzoxazone and Cinnarizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Cinnarizine belongs to Respiratory.
Why it happens
Additive CNS depression.
What to do
Counsel the patient about drowsiness and driving, and reduce the dose of one agent if sedation is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Other interactions of Cinnarizine
- Alprazolam + Cinnarizine Moderate
- Amitriptyline + Cinnarizine Moderate
- Amobarbital + Cinnarizine Moderate
- Aripiprazole + Cinnarizine Moderate
- Azelastine-fluticasone + Cinnarizine Moderate
- Azelastine + Cinnarizine Moderate
Frequently asked questions
Can I take Chlorzoxazone with Cinnarizine?
MediHelp rates the interaction as moderate. Chlorzoxazone and Cinnarizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cinnarizine has sedating antihistamine properties and may add to chlorzoxazone-related drowsiness. This can impair concentration and coordination.
How serious is the interaction between Chlorzoxazone and Cinnarizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient about drowsiness and driving, and reduce the dose of one agent if sedation is excessive.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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