Drug interactions
Chlorzoxazone + Clobazam
Severity: Moderate
Chlorzoxazone and Clobazam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam is a benzodiazepine and chlorzoxazone is a sedating muscle relaxant, so concurrent use increases drowsiness, psychomotor impairment and, at higher exposures, respiratory depression. Elderly or debilitated patients are at greater risk.
What this interaction means in plain words
Chlorzoxazone and Clobazam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Clobazam belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A potentiation by clobazam and central muscle relaxation by chlorzoxazone.
What to do
Use the lowest effective doses for the shortest duration and monitor for sedation and respiratory depression. Counsel patients against driving and against alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Chlorzoxazone with Clobazam?
MediHelp rates the interaction as moderate. Chlorzoxazone and Clobazam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clobazam is a benzodiazepine and chlorzoxazone is a sedating muscle relaxant, so concurrent use increases drowsiness, psychomotor impairment and, at higher exposures, respiratory depression. Elderly or debilitated patients are at greater risk.
How serious is the interaction between Chlorzoxazone and Clobazam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest duration and monitor for sedation and respiratory depression. Counsel patients against driving and against alcohol.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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