Drug interactions
Chlorzoxazone + Dexchlorpheniramine
Severity: Moderate
Chlorzoxazone and Dexchlorpheniramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexchlorpheniramine is a sedating antihistamine and chlorzoxazone also causes drowsiness. Together they can cause marked sedation and reduced psychomotor performance.
What this interaction means in plain words
Chlorzoxazone and Dexchlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Dexchlorpheniramine belongs to Respiratory.
Why it happens
Additive CNS depression from central H1-receptor blockade and the central muscle relaxant action of chlorzoxazone.
What to do
Counsel the patient to avoid driving and hazardous activities until the combined effect is known. Prefer a non-sedating antihistamine if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Other interactions of Dexchlorpheniramine
- Alprazolam + Dexchlorpheniramine Moderate
- Amisulpride + Dexchlorpheniramine Moderate
- Amitriptyline + Dexchlorpheniramine Moderate
- Amobarbital + Dexchlorpheniramine Moderate
- Asenapine + Dexchlorpheniramine Moderate
- Azelastine-fluticasone + Dexchlorpheniramine Moderate
Frequently asked questions
Can I take Chlorzoxazone with Dexchlorpheniramine?
MediHelp rates the interaction as moderate. Chlorzoxazone and Dexchlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexchlorpheniramine is a sedating antihistamine and chlorzoxazone also causes drowsiness. Together they can cause marked sedation and reduced psychomotor performance.
How serious is the interaction between Chlorzoxazone and Dexchlorpheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to avoid driving and hazardous activities until the combined effect is known. Prefer a non-sedating antihistamine if possible.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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