Drug interactions
Chlorzoxazone + Difelikefalin
Severity: Moderate
Chlorzoxazone and Difelikefalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difelikefalin, a kappa-opioid agonist, can cause somnolence and dizziness. Chlorzoxazone may add to these effects and impair alertness and balance, particularly in dialysis patients.
What this interaction means in plain words
Chlorzoxazone and Difelikefalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Difelikefalin belongs to Dermatology.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for somnolence, dizziness and falls after starting the combination. Reduce the chlorzoxazone dose if sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Other interactions of Difelikefalin
- Acetazolamide + Difelikefalin Moderate
- Alprazolam + Difelikefalin Moderate
- Amantadine + Difelikefalin Moderate
- Amitriptyline + Difelikefalin Moderate
- Amobarbital + Difelikefalin Moderate
- Asenapine + Difelikefalin Moderate
Frequently asked questions
Can I take Chlorzoxazone with Difelikefalin?
MediHelp rates the interaction as moderate. Chlorzoxazone and Difelikefalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difelikefalin, a kappa-opioid agonist, can cause somnolence and dizziness. Chlorzoxazone may add to these effects and impair alertness and balance, particularly in dialysis patients.
How serious is the interaction between Chlorzoxazone and Difelikefalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for somnolence, dizziness and falls after starting the combination. Reduce the chlorzoxazone dose if sedation occurs.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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