Drug interactions
Chlorzoxazone + Etomidate
Severity: Minor
Chlorzoxazone and Etomidate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etomidate is an intravenous anesthetic induction agent, and chlorzoxazone may add to its sedative effect. The interaction is of limited clinical importance because etomidate is given and titrated by anesthesia staff under monitoring.
What this interaction means in plain words
Chlorzoxazone and Etomidate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorzoxazone belongs to Musculoskeletal; Etomidate belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A potentiation by etomidate and central muscle relaxation.
What to do
Tell the anesthesia team about recent chlorzoxazone use so induction doses can be titrated to effect.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlorzoxazone
Other interactions of Etomidate
- Alprazolam + Etomidate Moderate
- Amitriptyline + Etomidate Moderate
- Amobarbital + Etomidate Moderate
- Azelastine + Etomidate Moderate
- Baclofen + Etomidate Moderate
- Brompheniramine + Etomidate Moderate
Frequently asked questions
Can I take Chlorzoxazone with Etomidate?
MediHelp rates the interaction as minor. Chlorzoxazone and Etomidate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Etomidate is an intravenous anesthetic induction agent, and chlorzoxazone may add to its sedative effect. The interaction is of limited clinical importance because etomidate is given and titrated by anesthesia staff under monitoring.
How serious is the interaction between Chlorzoxazone and Etomidate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Tell the anesthesia team about recent chlorzoxazone use so induction doses can be titrated to effect.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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