Drug interactions
Chlorzoxazone + Flibanserin
Severity: Moderate
Chlorzoxazone and Flibanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorzoxazone is a CYP2E1 substrate and a sedating muscle relaxant. It is not a recognized CYP3A4 inhibitor, but it adds to flibanserin-related drowsiness and dizziness.
What this interaction means in plain words
Chlorzoxazone and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Flibanserin belongs to Genitourinary.
Why it happens
Additive CNS depressant effects; no established CYP3A4 inhibition.
What to do
Monitor for excessive sedation and dizziness. Counsel the patient about driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Chlorzoxazone
Frequently asked questions
Can I take Chlorzoxazone with Flibanserin?
MediHelp rates the interaction as moderate. Chlorzoxazone and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorzoxazone is a CYP2E1 substrate and a sedating muscle relaxant. It is not a recognized CYP3A4 inhibitor, but it adds to flibanserin-related drowsiness and dizziness.
How serious is the interaction between Chlorzoxazone and Flibanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and dizziness. Counsel the patient about driving and alcohol.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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