Drug interactions
Chlorzoxazone + Fluphenazine
Severity: Moderate
Chlorzoxazone and Fluphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine can cause sedation, and with chlorzoxazone the drowsiness and psychomotor slowing may be greater. Extrapyramidal effects are not clearly altered, but falls and impaired alertness are a concern.
What this interaction means in plain words
Chlorzoxazone and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Fluphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression.
What to do
Monitor for excess sedation and dizziness and counsel on driving. Reduce the dose of one drug if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Chlorzoxazone with Fluphenazine?
MediHelp rates the interaction as moderate. Chlorzoxazone and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluphenazine can cause sedation, and with chlorzoxazone the drowsiness and psychomotor slowing may be greater. Extrapyramidal effects are not clearly altered, but falls and impaired alertness are a concern.
How serious is the interaction between Chlorzoxazone and Fluphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and dizziness and counsel on driving. Reduce the dose of one drug if needed.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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