Drug interactions
Chlorzoxazone + Hydroxyzine
Severity: Moderate
Chlorzoxazone and Hydroxyzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine is a sedating antihistamine and anxiolytic that can enhance chlorzoxazone drowsiness. Reduced alertness, slowed reactions and falls may occur, especially in older patients.
What this interaction means in plain words
Chlorzoxazone and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Hydroxyzine belongs to Respiratory.
Why it happens
Additive CNS depression.
What to do
Use the lowest effective doses and counsel on driving and alcohol. Avoid in older adults where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Chlorzoxazone with Hydroxyzine?
MediHelp rates the interaction as moderate. Chlorzoxazone and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyzine is a sedating antihistamine and anxiolytic that can enhance chlorzoxazone drowsiness. Reduced alertness, slowed reactions and falls may occur, especially in older patients.
How serious is the interaction between Chlorzoxazone and Hydroxyzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and counsel on driving and alcohol. Avoid in older adults where possible.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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