Drug interactions
Chlorzoxazone + Iloperidone
Severity: Moderate
Chlorzoxazone and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone can cause sedation, dizziness and orthostatic hypotension, and chlorzoxazone adds to drowsiness. Together they may increase impairment and the risk of falls.
What this interaction means in plain words
Chlorzoxazone and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Iloperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression and sedation from antipsychotic receptor blockade plus central muscle relaxation.
What to do
Monitor for sedation, dizziness and orthostatic blood pressure changes. Reduce the chlorzoxazone dose if impairment develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Chlorzoxazone with Iloperidone?
MediHelp rates the interaction as moderate. Chlorzoxazone and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone can cause sedation, dizziness and orthostatic hypotension, and chlorzoxazone adds to drowsiness. Together they may increase impairment and the risk of falls.
How serious is the interaction between Chlorzoxazone and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, dizziness and orthostatic blood pressure changes. Reduce the chlorzoxazone dose if impairment develops.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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