Drug interactions
Chlorzoxazone + Lasmiditan
Severity: Moderate
Chlorzoxazone and Lasmiditan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness and dizziness, and lasmiditan also impairs psychomotor performance. Taken together, sedation and impaired alertness may be greater than with either drug alone.
What this interaction means in plain words
Chlorzoxazone and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Lasmiditan belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Counsel the patient to avoid driving or operating machinery for at least 8 hours after a lasmiditan dose. Watch for excess sedation when a muscle relaxant is used at the same time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Chlorzoxazone with Lasmiditan?
MediHelp rates the interaction as moderate. Chlorzoxazone and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness and dizziness, and lasmiditan also impairs psychomotor performance. Taken together, sedation and impaired alertness may be greater than with either drug alone.
How serious is the interaction between Chlorzoxazone and Lasmiditan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to avoid driving or operating machinery for at least 8 hours after a lasmiditan dose. Watch for excess sedation when a muscle relaxant is used at the same time.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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