Drug interactions
Chlorzoxazone + Meperidine
Severity: Moderate
Chlorzoxazone and Meperidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorzoxazone is a centrally acting muscle relaxant that may add to opioid sedation and impair alertness and coordination. Respiratory depression is possible, particularly at higher doses.
What this interaction means in plain words
Chlorzoxazone and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Meperidine belongs to Musculoskeletal.
Why it happens
Additive CNS depression.
What to do
Use the lowest effective doses and monitor for excessive drowsiness. Advise patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Other interactions of Chlorzoxazone
Frequently asked questions
Can I take Chlorzoxazone with Meperidine?
MediHelp rates the interaction as moderate. Chlorzoxazone and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorzoxazone is a centrally acting muscle relaxant that may add to opioid sedation and impair alertness and coordination. Respiratory depression is possible, particularly at higher doses.
How serious is the interaction between Chlorzoxazone and Meperidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for excessive drowsiness. Advise patients to avoid driving and alcohol.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
Full monographs, dosing and an interaction checker in the MediHelp app
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