Drug interactions
Chlorzoxazone + Pentazocine
Severity: Moderate
Chlorzoxazone and Pentazocine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorzoxazone is a centrally acting muscle relaxant that causes drowsiness. With pentazocine, sedation and psychomotor impairment may be increased.
What this interaction means in plain words
Chlorzoxazone and Pentazocine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Pentazocine belongs to Musculoskeletal.
Why it happens
Additive central nervous system depression.
What to do
Use the lowest effective doses and monitor for excessive sedation and respiratory depression. Counsel patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pentazocine
- Calcium / magnesium / potassium / sodium oxybates + Pentazocine Contraindicated
- Olanzapine / samidorphan + Pentazocine Contraindicated
- Pentazocine + Phenelzine Contraindicated
- Pentazocine + Tranylcypromine Contraindicated
- Alfentanil + Pentazocine Major
- Alprazolam + Pentazocine Major
Other interactions of Chlorzoxazone
Frequently asked questions
Can I take Chlorzoxazone with Pentazocine?
MediHelp rates the interaction as moderate. Chlorzoxazone and Pentazocine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorzoxazone is a centrally acting muscle relaxant that causes drowsiness. With pentazocine, sedation and psychomotor impairment may be increased.
How serious is the interaction between Chlorzoxazone and Pentazocine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for excessive sedation and respiratory depression. Counsel patients to avoid driving and alcohol.
What other medicines interact with Pentazocine?
MediHelp also lists interactions of Pentazocine with, for example, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan, Phenelzine. The full list is on the Pentazocine page.
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