Drug interactions
Chlorzoxazone + Perphenazine
Severity: Moderate
Chlorzoxazone and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine can cause sedation and orthostatic hypotension, which may add to chlorzoxazone drowsiness. Impaired alertness and falls are the main risks.
What this interaction means in plain words
Chlorzoxazone and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Perphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression from dopamine, histamine and adrenergic blockade combined with muscle relaxant sedation.
What to do
Monitor for oversedation and orthostatic hypotension, and counsel on driving. Reduce the dose of one agent if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Chlorzoxazone with Perphenazine?
MediHelp rates the interaction as moderate. Chlorzoxazone and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine can cause sedation and orthostatic hypotension, which may add to chlorzoxazone drowsiness. Impaired alertness and falls are the main risks.
How serious is the interaction between Chlorzoxazone and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and orthostatic hypotension, and counsel on driving. Reduce the dose of one agent if needed.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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