Drug interactions
Chlorzoxazone + Temazepam
Severity: Moderate
Chlorzoxazone and Temazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taking a centrally acting muscle relaxant with a benzodiazepine hypnotic can increase drowsiness, dizziness, impaired coordination and fall risk. Older patients are particularly vulnerable.
What this interaction means in plain words
Chlorzoxazone and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Temazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression.
What to do
Use the lowest effective doses and avoid alcohol. Advise against driving after dosing and monitor older adults for falls and confusion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Chlorzoxazone with Temazepam?
MediHelp rates the interaction as moderate. Chlorzoxazone and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Taking a centrally acting muscle relaxant with a benzodiazepine hypnotic can increase drowsiness, dizziness, impaired coordination and fall risk. Older patients are particularly vulnerable.
How serious is the interaction between Chlorzoxazone and Temazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and avoid alcohol. Advise against driving after dosing and monitor older adults for falls and confusion.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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