Drug interactions
Cholera vaccine + Leflunomide
Severity: Moderate
Cholera vaccine and Leflunomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leflunomide can blunt the immune response to vaccines. An oral cholera vaccine may give weaker protection in treated patients. The vaccine in question is generally non-live, so safety concerns are limited.
What this interaction means in plain words
Cholera vaccine and Leflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Leflunomide's immunosuppressive inhibition of lymphocyte proliferation reduces vaccine antibody responses.
What to do
If feasible, vaccinate before starting leflunomide. Otherwise vaccinate and consider checking response or revaccinating if protection is important.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cholera vaccine and Leflunomide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicated
- Leflunomide + Measles mumps and rubella vaccine live Contraindicated
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
Frequently asked questions
Can I take Cholera vaccine with Leflunomide?
MediHelp rates the interaction as moderate. Cholera vaccine and Leflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leflunomide can blunt the immune response to vaccines. An oral cholera vaccine may give weaker protection in treated patients. The vaccine in question is generally non-live, so safety concerns are limited.
How serious is the interaction between Cholera vaccine and Leflunomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If feasible, vaccinate before starting leflunomide. Otherwise vaccinate and consider checking response or revaccinating if protection is important.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
