Drug interactions
Cholera vaccine + Lincomycin
Severity: Moderate
Cholera vaccine and Lincomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cholera vaccine (live attenuated oral) relies on viable bacteria colonizing the gut. Systemic antibiotics with activity against the strain may kill the vaccine organism and reduce the immune response.
What this interaction means in plain words
Cholera vaccine and Lincomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity against the live attenuated vaccine strain reduces vaccine viability and immunogenicity.
What to do
Avoid giving the live oral cholera vaccine to patients who have taken systemic antibiotics in the preceding 14 days, as labeled, and delay vaccination until the course is finished.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lincomycin
- Atracurium + Lincomycin Major
- Cisatracurium + Lincomycin Major
- Lincomycin + Pancuronium Major
- Lincomycin + Rapacuronium Major
- Lincomycin + Rocuronium Major
- Lincomycin + Vecuronium Major
Frequently asked questions
Can I take Cholera vaccine with Lincomycin?
MediHelp rates the interaction as moderate. Cholera vaccine and Lincomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cholera vaccine (live attenuated oral) relies on viable bacteria colonizing the gut. Systemic antibiotics with activity against the strain may kill the vaccine organism and reduce the immune response.
How serious is the interaction between Cholera vaccine and Lincomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving the live oral cholera vaccine to patients who have taken systemic antibiotics in the preceding 14 days, as labeled, and delay vaccination until the course is finished.
What other medicines interact with Lincomycin?
MediHelp also lists interactions of Lincomycin with, for example, Atracurium, Cisatracurium, Pancuronium. The full list is on the Lincomycin page.
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