Drug interactions
Lincomycin + Rocuronium
Severity: Major
Lincomycin and Rocuronium: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lincomycin has neuromuscular blocking activity and can potentiate rocuronium, prolonging paralysis and delaying return of spontaneous ventilation.
What this interaction means in plain words
Lincomycin and Rocuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lincomycin belongs to Anti Bacterial; Rocuronium belongs to Musculoskeletal.
Why it happens
Additive neuromuscular blockade via presynaptic and postsynaptic inhibition of transmission by lincomycin.
What to do
Monitor train-of-four and titrate rocuronium cautiously. Keep ventilatory support available until full recovery.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Rocuronium
Other interactions of Lincomycin
- Atracurium + Lincomycin Major
- Cisatracurium + Lincomycin Major
- Lincomycin + Pancuronium Major
- Lincomycin + Rapacuronium Major
- Lincomycin + Vecuronium Major
- Cholera vaccine + Lincomycin Moderate
Frequently asked questions
Can I take Lincomycin with Rocuronium?
MediHelp rates the interaction as major. Lincomycin and Rocuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lincomycin has neuromuscular blocking activity and can potentiate rocuronium, prolonging paralysis and delaying return of spontaneous ventilation.
How serious is the interaction between Lincomycin and Rocuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor train-of-four and titrate rocuronium cautiously. Keep ventilatory support available until full recovery.
What other medicines interact with Rocuronium?
MediHelp also lists interactions of Rocuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Rocuronium page.
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