Drug interactions
Lincomycin + Pancuronium
Severity: Major
Lincomycin and Pancuronium: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lincomycin can potentiate pancuronium and prolong neuromuscular blockade. Delayed recovery and respiratory depression have been described with this class combination.
What this interaction means in plain words
Lincomycin and Pancuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lincomycin belongs to Anti Bacterial; Pancuronium belongs to Musculoskeletal.
Why it happens
Lincomycin has weak intrinsic neuromuscular blocking activity that adds to pancuronium's effect.
What to do
Titrate pancuronium with train-of-four monitoring and maintain ventilatory support until recovery is confirmed. Choose a different antibiotic if practical.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pancuronium
Other interactions of Lincomycin
- Atracurium + Lincomycin Major
- Cisatracurium + Lincomycin Major
- Lincomycin + Rapacuronium Major
- Lincomycin + Rocuronium Major
- Lincomycin + Vecuronium Major
- Cholera vaccine + Lincomycin Moderate
Frequently asked questions
Can I take Lincomycin with Pancuronium?
MediHelp rates the interaction as major. Lincomycin and Pancuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lincomycin can potentiate pancuronium and prolong neuromuscular blockade. Delayed recovery and respiratory depression have been described with this class combination.
How serious is the interaction between Lincomycin and Pancuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate pancuronium with train-of-four monitoring and maintain ventilatory support until recovery is confirmed. Choose a different antibiotic if practical.
What other medicines interact with Pancuronium?
MediHelp also lists interactions of Pancuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Pancuronium page.
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