Drug interactions
Lincomycin + Vecuronium
Severity: Major
Lincomycin and Vecuronium: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lincosamides can potentiate non-depolarising muscle relaxants and prolong neuromuscular blockade. Reports describe delayed recovery and respiratory depression after combined use.
What this interaction means in plain words
Lincomycin and Vecuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lincomycin belongs to Anti Bacterial; Vecuronium belongs to Musculoskeletal.
Why it happens
Lincomycin has weak intrinsic neuromuscular blocking activity acting at pre- and postsynaptic sites, adding to vecuronium's effect.
What to do
Monitor neuromuscular function with a train-of-four monitor and titrate vecuronium to effect. Ensure ventilatory support until recovery is complete, or choose a different antibiotic.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vecuronium
Other interactions of Lincomycin
- Atracurium + Lincomycin Major
- Cisatracurium + Lincomycin Major
- Lincomycin + Pancuronium Major
- Lincomycin + Rapacuronium Major
- Lincomycin + Rocuronium Major
- Cholera vaccine + Lincomycin Moderate
Frequently asked questions
Can I take Lincomycin with Vecuronium?
MediHelp rates the interaction as major. Lincomycin and Vecuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lincosamides can potentiate non-depolarising muscle relaxants and prolong neuromuscular blockade. Reports describe delayed recovery and respiratory depression after combined use.
How serious is the interaction between Lincomycin and Vecuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with a train-of-four monitor and titrate vecuronium to effect. Ensure ventilatory support until recovery is complete, or choose a different antibiotic.
What other medicines interact with Vecuronium?
MediHelp also lists interactions of Vecuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Vecuronium page.
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