Drug interactions
Cholera vaccine + Lomustine
Severity: Moderate
Cholera vaccine and Lomustine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomustine-related immunosuppression may reduce the antibody response to cholera vaccine. Oral cholera vaccines are live in some formulations, which adds a theoretical infection risk, although the main concern is reduced protection.
What this interaction means in plain words
Cholera vaccine and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic immunosuppression blunts the immune response, and replication of live-attenuated strains is less well controlled.
What to do
If possible, vaccinate before chemotherapy or after immune recovery. Prefer an inactivated formulation during treatment and do not rely on the vaccine for protection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Cholera vaccine with Lomustine?
MediHelp rates the interaction as moderate. Cholera vaccine and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomustine-related immunosuppression may reduce the antibody response to cholera vaccine. Oral cholera vaccines are live in some formulations, which adds a theoretical infection risk, although the main concern is reduced protection.
How serious is the interaction between Cholera vaccine and Lomustine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If possible, vaccinate before chemotherapy or after immune recovery. Prefer an inactivated formulation during treatment and do not rely on the vaccine for protection.
What other medicines interact with Lomustine?
MediHelp also lists interactions of Lomustine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Lomustine page.
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