Drug interactions
Cholestyramine + Lomitapide
Severity: Moderate
Cholestyramine and Lomitapide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bile acid sequestrants can bind lomitapide in the gut and lower its absorption, reducing lipid-lowering efficacy.
What this interaction means in plain words
Cholestyramine and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholestyramine belongs to Cardiovascular; Lomitapide belongs to Cardiovascular.
Why it happens
Resin binding of lomitapide in the gastrointestinal tract reduces absorption.
What to do
Separate lomitapide and cholestyramine by at least 4 hours. Monitor LDL cholesterol response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cholestyramine
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Cholestyramine with Lomitapide?
MediHelp rates the interaction as moderate. Cholestyramine and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bile acid sequestrants can bind lomitapide in the gut and lower its absorption, reducing lipid-lowering efficacy.
How serious is the interaction between Cholestyramine and Lomitapide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate lomitapide and cholestyramine by at least 4 hours. Monitor LDL cholesterol response.
What other medicines interact with Cholestyramine?
MediHelp also lists interactions of Cholestyramine with, for example, Cholic acid, Deferasirox, Leflunomide. The full list is on the Cholestyramine page.
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