Drug interactions
Cholestyramine + Piroxicam
Severity: Moderate
Cholestyramine and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cholestyramine binds piroxicam in the gut and reduces its absorption. It also interrupts enterohepatic recirculation and so speeds piroxicam elimination, lowering its effect.
What this interaction means in plain words
Cholestyramine and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholestyramine belongs to Cardiovascular; Piroxicam belongs to Musculoskeletal.
Why it happens
Binding of piroxicam by the anion-exchange resin in the gastrointestinal tract reduces absorption and interrupts enterohepatic recirculation.
What to do
Give piroxicam at least 1 hour before or 4 to 6 hours after cholestyramine. Monitor analgesic response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Cholestyramine
Frequently asked questions
Can I take Cholestyramine with Piroxicam?
MediHelp rates the interaction as moderate. Cholestyramine and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cholestyramine binds piroxicam in the gut and reduces its absorption. It also interrupts enterohepatic recirculation and so speeds piroxicam elimination, lowering its effect.
How serious is the interaction between Cholestyramine and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give piroxicam at least 1 hour before or 4 to 6 hours after cholestyramine. Monitor analgesic response.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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