Drug interactions
Cidofovir + Ifosfamide
Severity: Major
Cidofovir and Ifosfamide: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ifosfamide can cause proximal tubular injury and reduced glomerular filtration, and cidofovir is itself nephrotoxic. Together they greatly increase the likelihood of renal damage. Cidofovir labeling advises against use with other nephrotoxic drugs.
What this interaction means in plain words
Cidofovir and Ifosfamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cidofovir belongs to Anti Virals; Ifosfamide belongs to Oncology.
Why it happens
Additive nephrotoxicity affecting the proximal renal tubule.
What to do
Avoid the combination if possible; if essential, ensure hydration with probenecid per cidofovir protocol and closely monitor creatinine, electrolytes and urine protein.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Cidofovir
- Amikacin + Cidofovir Contraindicated
- Amphotericin b deoxycholate + Cidofovir Contraindicated
- Amphotericin b + Cidofovir Contraindicated
- Bacitracin + Cidofovir Contraindicated
- Capreomycin + Cidofovir Contraindicated
- Cephaloridine + Cidofovir Contraindicated
Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Cidofovir with Ifosfamide?
MediHelp rates the interaction as major. Cidofovir and Ifosfamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ifosfamide can cause proximal tubular injury and reduced glomerular filtration, and cidofovir is itself nephrotoxic. Together they greatly increase the likelihood of renal damage. Cidofovir labeling advises against use with other nephrotoxic drugs.
How serious is the interaction between Cidofovir and Ifosfamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; if essential, ensure hydration with probenecid per cidofovir protocol and closely monitor creatinine, electrolytes and urine protein.
What other medicines interact with Cidofovir?
MediHelp also lists interactions of Cidofovir with, for example, Amikacin, Amphotericin b deoxycholate, Amphotericin b. The full list is on the Cidofovir page.
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