Drug interactions
Cidofovir + Streptomycin
Severity: Major
Cidofovir and Streptomycin: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can injure the kidney, and streptomycin can also damage the inner ear. Using them together raises the risk of acute kidney injury and may worsen ototoxicity. Cidofovir is already associated with proximal tubular toxicity, so added aminoglycoside exposure is clinically important.
What this interaction means in plain words
Cidofovir and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cidofovir belongs to Anti Virals; Streptomycin belongs to Anti Bacterial.
Why it happens
Additive nephrotoxicity from proximal tubular injury caused by cidofovir and aminoglycoside accumulation in the renal cortex.
What to do
Avoid the combination where possible; cidofovir labeling advises against concurrent nephrotoxic agents. If unavoidable, monitor serum creatinine and urine protein before each cidofovir dose and monitor streptomycin levels and hearing.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Streptomycin
Other interactions of Cidofovir
- Amikacin + Cidofovir Contraindicated
- Amphotericin b deoxycholate + Cidofovir Contraindicated
- Amphotericin b + Cidofovir Contraindicated
- Bacitracin + Cidofovir Contraindicated
- Capreomycin + Cidofovir Contraindicated
- Cephaloridine + Cidofovir Contraindicated
Frequently asked questions
Can I take Cidofovir with Streptomycin?
MediHelp rates the interaction as major. Cidofovir and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can injure the kidney, and streptomycin can also damage the inner ear. Using them together raises the risk of acute kidney injury and may worsen ototoxicity. Cidofovir is already associated with proximal tubular toxicity, so added aminoglycoside exposure is clinically important.
How serious is the interaction between Cidofovir and Streptomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; cidofovir labeling advises against concurrent nephrotoxic agents. If unavoidable, monitor serum creatinine and urine protein before each cidofovir dose and monitor streptomycin levels and hearing.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
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